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☣️ Pleb Kruse = BTC foundationalist in exile 🟩🔆
@DrJackKruse
Regrowing teeth using light to inhibit BMPs might present potential. And this important research is going on with new results. South Korea developed a patch that regrows teeth — ending dentures forever 🦷 Scientists at Seoul National University have created a microneedle patch that stimulates dormant tooth stem cells to regenerate enamel and even grow entirely new teeth in adult humans. The patch contains a drug called tideglusib combined with growth factors that activate dental stem cells still present in the jaw. Clinical trials showed remarkable results: Small cavities completely healed in 4-6 weeks Chipped teeth regrew enamel within 8 weeks In 30% of participants, completely new tooth buds began forming No pain, no drilling, no fillings needed How it works: The patch is applied to the gum above the damaged tooth for 20 minutes daily. Microneedles penetrate the gum tissue painlessly, delivering the drug directly to the tooth root where stem cells reside. The drug inhibits a protein (GSK-3) that normally prevents tooth regeneration in adults. This could revolutionize dentistry: 3.5 billion people suffer from oral diseases Dental tourism generates $10 billion annually Dentures and implants cost $10,000-$40,000 Regrown teeth are genetically your own—no rejection risk South Korea plans to commercialize the patches by 2026, pricing them at around $300 per tooth—a fraction of implant costs. The same technology might work for regrowing bone in other parts of the body. Source: Seoul National University School of Dentistry, Science Translational Medicine 2025
First image is a text diagram titled How It All Works: The Three Keys to Understand explaining research on regrowing teeth naturally using abbreviations USAG-1 as a protein coded by a specific gene that suppresses tooth growth, BMPs as bone morphogenetic proteins regulating bone and organ development to help new teeth form, and TRG403 as a monoclonal antibody inhibiting USAG-1 so antibodies were named TRG403 facilitating growth of new teeth with the drug containing TRG403 in optimal pharmaceutical form doses and routes of administration. Second image shows a close-up view of a transparent microneedle patch device with fine needle-like structures and emerging white tooth-like forms inside a gel-like substance against a dark background representing South Korea developed patch that regrows teeth.
First image is a text diagram titled How It All Works: The Three Keys to Understand explaining research on regrowing teeth naturally using abbreviations USAG-1 as a protein coded by a specific gene that suppresses tooth growth, BMPs as bone morphogenetic proteins regulating bone and organ development to help new teeth form, and TRG403 as a monoclonal antibody inhibiting USAG-1 so antibodies were named TRG403 facilitating growth of new teeth with the drug containing TRG403 in optimal pharmaceutical form doses and routes of administration. Second image shows a close-up view of a transparent microneedle patch device with fine needle-like structures and emerging white tooth-like forms inside a gel-like substance against a dark background representing South Korea developed patch that regrows teeth.
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Dr. Stephen Coates
@scdds87
They have been working on gene slicing and developing new tooth buds for 30 years plus. We should be able to grow teeth at one point. The statement that a chipped tooth can grow enamel is impossible. To make that statement does not understand the histology of how a tooth forms.
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Jimmy G
@6jimmyg
I had an accident and damaged my lateral inciser tooth. It became loose over time until it fell. to my surprise, there was a new one coming and still making its way down..I am 35. According to dentist I am extremely lucky..
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NanoMa44
@NanoMa44
Are the stem cells still present in abundance if someone has had wisdom teeth extracted? I read somewhere wisdom teeth hold a lot of stem cells:) Just curious
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SpiderMonkey ☀️
@SpiderMonkeyXYZ
Jack, I’d love to know your thoughts on how we humans can build technology the right way, If I remember correctly you’ve mentioned in the past how that our investment in tech has led to more health issues, cancers etc developing, I dont think the answer is to go full Armish,
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JP
@JDPAUL85
This is interesting. I’ve heard of this before, seems like it won’t happen for many more years due to the impact it would have on the dental field and all the companies that profit off the industry. I wonder if the patients would need ortho to align new teeth.
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HaasCat
@Haas_Cat
If our health/insurance cartels can figure out how to inflate prices and monetize this…maybe this can be a thing here And maybe our government can make it to where people in other countries can get it for free. Or heck maybe that should be the focus….then us last 😐
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Shadow Client
@theshadowclient
what are thoughts on red light toothbrush? difference bw therapeutic red light wavelength and LED red visible light? does sunlight have effect on teeth?
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JJ Jones
@JJJones88972322
Dick Algire and his wife just got back from Korea, where they both had stem cell therapy. They filmed it, and it’s very interesting.
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Nik M
@m1134322
There is research of similar too regrowtb in Canada some years ago
Answer by Grok
Yes, you're right—there has been notable research on tooth regrowth and regeneration in Canada dating back over a decade, particularly focused on dental root repair and tissue stimulation. One of the most prominent early efforts came from the University of Alberta in the mid-2000s, led by Dr. Tarek El-Bialy, an associate professor of orthodontics and biomedical engineering. This work used low-intensity pulsed ultrasound (LIPUS) to stimulate the regrowth of damaged tooth roots, a common issue in orthodontic patients (e.g., from braces causing root resorption) or those with gum disease-related bone loss. Key Details on the Alberta Ultrasound Research: Method: A compact, wireless ultrasound device (like a "system-on-a-chip") was designed to fit inside the mouth, mounted on braces or a crown. It delivers non-invasive pulses to promote jawbone growth and dental tissue healing, with later phases exploring integration with patients' own stem cells from oral tissues. Outcomes: In rabbit studies, treated teeth showed significant new tissue formation compared to untreated controls. Human trials were in early stages by 2010, with promising results for preventing further root damage and enabling continued orthodontics. Timeline and Funding: The prototype was developed around 2006, with a patent pending through TEC Edmonton. Impact: This could benefit the millions of North Americans in braces (potential market of 1.4 million users) and those with congenital jaw issues like hemifacial microsomia. Follow-up work by 2020 showed the device also speeds up orthodontic treatment by up to 60% and reduces root resorption. More recent Canadian efforts build on similar regenerative themes: University of Toronto (Ongoing, ~2020s): Researchers like assistant professor Karina Carneiro are using DNA nanotechnology to create gels that act as scaffolds for dentin remineralization. In rat models, this has accelerated bone healing; the goal is to apply it to human teeth for cavity repair without fillings or root canals, promoting minimally invasive pediatric dentistry. University of Manitoba (2024): Scientists are studying regenerative abilities in tropical fish (like zebrafish) to inspire new tooth regrowth techniques in humans, focusing on stem cell activation. This Alberta work from "some years ago" shares conceptual similarities with the Japanese antibody trials (e.g., targeting growth pathways for budding/regeneration) but emphasizes ultrasound stimulation over drugs. If you're thinking of a specific study or want deeper dives into any of these, let me know!
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